NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization

A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy.

The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. The reported BA-BDPA radical meets all the requirements to become a promising candidate for its use in in vivo DNP-NMR expe...

Scavenging free radicals to preserve enhancement and extend relaxation times in NMR using dynamic nuclear polarization.

Dynamic nuclear polarization (DNP) can enhance the nuclear polarization, that is the difference between the populations of the Zeeman levels jai and jbi of spin I= 1/2, by up to four orders of magnitude with respect to their Boltzmann distribution at room temperature. This enhancement arises from thermal mixing, which is brought about by microwave saturation of the EPR transitions of stable rad...

BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.

Optimizing dissolution dynamic nuclear polarization.

This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows. (i) Using broad line polarizing agents to efficiently polarize 1H spins. (ii) Increasing the ...

Novel PTM-TEMPO biradical for fast dissolution dynamic nuclear polarization.

The synthesis and characterization of a novel trityl-TEMPO biradical and the investigation of its properties as Dynamic Nuclear Polarization (DNP) polarizing agent are reported. Comparison with a structurally related monoradical (PTM-TEMPE) or mixtures of the two monoradical components reveals that the biradical has a much higher polarization efficiency and a faster polarization buildup. This o...